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Emphasize to individuals as well as their caregivers the value of reading through the Medication Guide that they may get from their pharmacist each and every time an opioid analgesic is dispensed to them.Renal impairment: Elimination fifty percent-existence prolonged with conclusion-stage renal impairment; dose reduction may be requiredEvaluate pat

Notice newborns for indications of neonatal opioid withdrawal syndrome and manage appropriately. Suggest pregnant Women of all ages applying opioids for a protracted duration of the risk of neonatal opioid withdrawal syndrome and make sure that correct cure will be accessible [see PRECAUTIONS; Information and facts FOR Clients/CAREGIVERS, PREGNANCY